I just finished a commission piece for the NAEYC (National Association for Education of Young Children). The sketch they approved was one of a teacher blowing bubbles to gleeful toddlers. They asked that I add the initials of their organization and some glasses on the teacher. So here's what I ended up doing: blowing up my drawing until it was 36" X 26". I traced each figure with wire, and then I filled each shape with curls of plastic wire, and stripes of pipe cleaner. I stitched upholstery fabric, strung beads, and wrapped wire mesh.
I have no control over what color the wall will be behind this piece, and so I tried it out on several walls to make sure each part had enough contrast to be seen from a distance.